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Analyses of the Effects of Wild-Type TDP-43 Overexpression in Oxytocin Neurons in Mice

Bergh S, Simonsson O and Petersén Å.

Neuropathology and Applied Neurobiology 52(1):e70059 (2026)

Abstract

Selective TDP-43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin-immunopositive cells compared to uninjected mice. AAV-mediated TDP-43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and metabolic phenotypes in mice.

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Last updated: 22 Jan 2026