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Program
09.30-10.00 Registration and coffee
10.00-10.15 Welcome and presentation of the Huntington Disease Center (chair Åsa Petersén, Lund)
10.15-11.00 Data blitz presentations- Clinical research (10 min + 5 min Q&A; chair Lena Hjermind, Copenhagen)
10.15-10.30 Distribution of CAG repeats in Northern Sweden (Valter Niemelä, Uppsala)
10.30-10.45 Huntington’s disease and proteomics (Niels Henning Skotte, Copenhagen)
10.45-11.00 Modelling Huntington’s disease using directly reprogrammed patient-derived neurons (Karolina Pircs, Lund
11.00-11.40 The role of the ubiquitin/proteasome system in the development of CAG triplet repeat disorders (Nico Dantuma, Stockholm; chair Åsa Petersén, Lund)
11.40-12.45 Lunch
12.45-14.00 Data blitz presentations - Mechanisms of disease (10 min + 5 min Q&A; chair Nico Dantuma, Stockholm)
12:45-13.00 Dynamic interaction of USP14 with HSC70 influences autophagy in HD (Vignesh Srinivasan, Helsinki)
13.00-13.15 Whole genome sequencing of HD families to identify novel rare variants that modify age of onset (Kristina Becanovic, Stockholm)
13.15-13.30 Satellite progenitor cell dysfunction in the R6/2 mouse model of Huntington disease (Rana Soylu-Kucharz, Lund)
13.30-13.45 HD cell models for studies of cellular and synaptic antioxidant systems (Luisana Carolina Duque Villegas, Copenhagen)
13.45-14.00 Effects of wild-type huntingtin protein expression in the hypothalamus of R6/2 and BACHD animal models (Elna Dickson, Lund)
14.00-14.30 Coffee break
14.30-15.30 Data blitz presentations - Future therapies (10 min + 5 min Q&A , chair Merja Voutilainen, Helsinki)
14.30-14.45 Effect of CDNF in animal models of Huntington`s disease (Polina Stepanova, Helsinki)
14.45-15.00 Role of the oxytocin-vasopressin system in Huntington's disease (Rachel Y Cheong, Lund)
15.00-15.15 First in class SORCS modulators for Huntington disease (Simon Molgaard, Aarhus)
15.15-15.30 CRISPR baser RNA therapy in a human model of Huntington's disease (Dzeneta Vizlin Hodzic, Gothenburg)
15.30-15.50 Break
15.50-16.45 Update on the activities of the European HD Network (EHDN) and clinical trials in Europe by EHDN co-chair Patrick Weydt, Bonn (chair Maria Björkqvist, Lund)
16.45-17.15 European HD Association and research by President of EHA Astri Arnesen, Norway (chair Åsa Petersén, Lund)
17.15-17.30 Final discussion (chairs Åsa Petersén and Maria Björkqvist, Lund)
18.00- 21.00 Networking and Meeting Dinner at Restaurant På Skissernas, Finngatan 2, Lund
Warm welcome!
Åsa Petersén, on behalf of the Huntington Center in Lund
Organizing committee: Maria Björkqvist, Jenny Månsson and Åsa Petersén.