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Rana Soylu Kucharz, PhD


2016 - ongoing: Postdoctoral fellowship, TNU, Medical Faculty, Lund University, Sweden


2009 - 2016: PhD studies in Neuroscience, Medical Faculty, Lund University, Sweden

Supervisor: Associate Professor Åsa Petersén.
Project: Molecular mechanisms of hypothalamic changes in Huntington’s disease.  

2008-2009: Course in Human Biology, preparatory course for postgraduate studies, Medical Faculty, Lund University, Sweden
Project: Neuropathological analysis after delivery of adeno- associated viral vectors expressing huntingtin fragments or cre-recombinase in the hypothalamus of mice.  
2005-2007: Masters Degree, Hacettepe University Institiute of Health Sciences, Medical Biology MSc Program, Ankara, Turkey
Supervisor: Associate Professor Cetin Kocaefe
Thesis: Characterization of muscle precursor cells on the course of chronic muscle degeneration. 
2001-2005: Bachelor Degree, Hacettepe University Faculty of Science, Department of Biology, Ankara, Turkey


Baldo B, Gabery S, Soylu-Kucharz R, Cheong RY, Henningsen JB, Englund E, McLean C, Kirik D, Halliday G and Petersén Å.
SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease.
Neuropathology and Applied Neurobiology. 2018 Jul 18. doi: 10.1111/nan.12514. [Epub ahead of print]

Soylu-Kucharz R, Sandelius Å, Sjögren M, Blennow K, Wild E, Zetterberg H and Björkqvist M.
Neurofilament Light Chain Levels in CSF and blood are associated with neurodegeneration and disease severity in the R6/2 mouse model of Huntington´s disease.
Scientific Reports 7:14114 (2017)

Soylu-Kucharz R, Baldo B and Petersén Å.
Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington's disease.
Scientific Reports 6: 28322 (2016)

Soylu-Kucharz R, Adlesic N, Baldo B, Kirik D and Petersén Å.
Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.
Sci Rep. Sep 30;5:14598 (2015)

Wiesner D, Sinniger J, Henriques A, Dieterlé S, Müller H, Rasche V, Ferger B, Dirrig-Grosch S, Soylu-Kucharz R, Petersén A, Walther P, Linkus B, Kassubek J, Wong PC, Ludolph AC and Dupuis L.
Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein mediated neurodegeneration.
Human Molecular Genetics 24(8): 2228-2240 (2015)

Baldo B, Soylu R and Petersén Å.
Maintenance of Basal Levels of Autophagy in Huntington’s Disease Mouse Models Displaying Metabolic Dysfunction.
PLOS ONE 8 (12) e83050 (2013)

Hult Lundh S, Nilsson N, Soylu R, Kirik D and Petersén Å.
Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease.
Human Molecular Genetics 22: 3485-3497 (2013)

Lundh SH, Soylu R and Petersén Å.
Expression of Mutant Huntingtin in Leptin Receptor-Expressing Neurons Does Not Control the Metabolic and Psychiatric Phenotype of the BACHD Mouse. 
PLoS ONE 7(12): e51168 (2012)

Gabery S, Sajjad MU, Hult S, Soylu R, Kirik D and Petersén Å.
Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.
European Journal of Neuroscience 36(6):2789-800 (2012)

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Rana Soylu Kucharz

Rana Soylu,  Post doc
Born in 1982
Phone: +46 46 222 45 57
E-mail: rana [dot] soylu_kucharz [at] med [dot] lu [dot] se (subject: E-mail%20from%20TNU%20website)

Lund University
Translational Neuroendocrinology Research Unit
Baravägen 27
221 84 Lund

Translational Neuroendocrine Research Unit
Baravägen 27, BMC D11
221 84 Lund